Lurasidone

Lurasidone
(loo-RAS-i-done)

Latuda

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Lurasidone is used to treat certain mental/mood disorders (such as schizophrenia, depression associated with bipolar disorder). Lurasidone helps you to think more clearly, feel less nervous, and take part in everyday life. It may also help to decrease hallucinations (hearing/seeing things that are not there). In addition, this medication may improve your mood, sleep, appetite, and energy level. Lurasidone is a psychiatric medication that belongs to the class of drugs called atypical antipsychotics.

It works by helping to restore the balance of certain natural substances in the brain.

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Other medications can affect the removal of lurasidone from your body, which may affect how lurasidone works. Examples include diltiazem, azole antifungals (such as ketoconazole, itraconazole), certain HIV/hepatitis C virus protease inhibitors (such as atazanavir, boceprevir, ritonavir), macrolide antibiotics (such as clarithromycin), rifamycins (such as rifampin, rifabutin), telithromycin, antidepressants (such as fluoxetine, paroxetine, nefazodone), among others.

Tell your doctor or pharmacist if you are taking other products that cause dizziness or drowsiness, including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Common side effects of Lurasidone include:

  • Drowsiness
  • Dizziness
  • Nausea
  • Shaking
  • Weight gain
  • Mask-like facial expression
  • Inability to keep still
  • Agitation

If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Your doctor may order another medication to lessen these effects.

This medication may cause a serious drop in blood pressure, especially when starting this medication. To reduce your risk of side effects from low blood pressure (such as dizziness), get up slowly when rising from a sitting or lying position.

Infrequently, this medication may cause face/muscle twitching and uncontrollable movements (tardive dyskinesia). In some cases, this condition may be permanent. Tell your doctor immediately if you develop any uncontrollable movements such as lip smacking, mouth puckering, tongue thrusting, chewing, or unusual arm/leg movements.

This drug may rarely make your blood sugar level rise, which can cause or worsen diabetes. Weight gain from this drug may increase the risk of this side effect. Tell your doctor immediately if you develop symptoms of high blood sugar such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugar level regularly.

This medication may also cause a rise in your blood fat levels (cholesterol and triglycerides). These increases, along with diabetes and weight gain, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor.

In rare cases, lurasidone may increase your level of a certain substance made by the body (prolactin). For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor immediately.

Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.

Get medical help right away if this serious side effect occurs: seizure.

This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, change in the amount of urine.